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Mixing, granulating, and coating can be performed in the same vessel and dense spherical granule is obtainable. Lineups from GMP design for pharmaceutical product, mass production scale, and laboratory type suitable for formulation research and experiment are available. After granulation, no screen type sizing machine can be used to make the particle size distribution narrower, with very high yield, without the problem of screen clogging. Extruder with precise temperature control can be used for preparation of highly uniform solid dispersion for solubility enhancement of pharmaceutical compounds.
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